منابع مشابه
Sampling strategies in nested case-control studies.
A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved matching of controls to cases with respect to confounding variables. However, in so...
متن کاملCase-Control Studies Are Not Familial Studies
Identifying rare genetic variants that drive the onset of disease is challenging, even before considering the additional genetic and environmental influences that likely exist in complex diseases. We recently published a study proposing a rare variant in the NR1H3 gene (p.R415Q, rs61731956) as responsible for the onset of multiple sclerosis (MS) in two multi-incident families (Wang et al., 2016...
متن کاملA relative power table for nested matched case-control studies.
OBJECTIVE To calculate relative powers for nested case-control studies for different values of both relative risk and numbers of controls per case, given a fixed number of cases available for analysis. METHODS Algebraic and numerical methods. RESULTS In nested case-control studies, statistical power is a function of relative risk, rarity of exposure, number of case-control sets, and the num...
متن کاملReuse of controls in nested case-control studies.
A frequently used study design within epidemiology is large cohort studies. In some situations additional information which is not included in the cohort, for instance biological material stored in biobanks, is required. The availability of such material is usually limited and might be very expensive to analyze for the entire cohort. A reasonable strategy is therefore to restrict the study samp...
متن کاملSTATISTICAL QUESTION Nested case-control studies: advantages and disadvantages
Researchers investigated whether antipsychotic drugs were associated with venous thromboembolism. A population based nested case-control study design was used. Data were taken from the UK QResearch primary care database consisting of 7 267 673 patients. Cases were adult patients with a first ever record of venous thromboembolism between 1 January 1996 and 1 July 2007. For each case, up to four ...
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ژورنال
عنوان ژورنال: Epidemiology
سال: 2009
ISSN: 1044-3983
DOI: 10.1097/ede.0b013e31819e370b